Quantifying the Effect of Consent for High–Kidney Donor Profile Index Deceased Donor Transplants in the United States

Quantifying the Effect of Consent for High–Kidney Donor Profile Index Deceased Donor Transplants in the United States
Jesse D. Schold, Kendra D. Conzen, James Cooper, Susana Arrigain, Rocio Lopez, Sumit Mohan, S. Ali Husain, Anne M. Huml, Peter T. Kennealey, Bruce Kaplan, Elizabeth A. Pomfret
Journal of the American Society of Nephrology, 13 February 2024
Abstract
Background
Despite known benefits of kidney transplantation, including transplantation from donors with increased risk factors, many waitlisted candidates die prior to transplantation. Consent to receive donor kidneys with lower expected survival (e.g. kidney donor profile index [KDPI]>85%) is typically obtained at waitlist placement. The presumed benefit of consent to receive high-KDPI donor kidneys is increased likelihood and timeliness of donor offers for transplantation. However, the specific impact of consent on access to transplantation is unclear. Our aims were to evaluate the characteristics of candidates consenting to high-KDPI donor kidneys and the likelihood of receiving a deceased donor transplant (DDTX) over time based on consent.
Methods
We used national Scientific Registry of Transplant Recipients data between 2015 and 2022(n=213,364). We evaluated the likelihood of consent using multivariable logistic models and time to DDTX with cumulative incidence plots accounting for competing risks and multivariable Cox models.
Results
Overall, high-KDPI consent was 41%, which was higher among candidates who were older, Black or Hispanic, had higher BMI, were diabetic, had vascular disease, and 12-48 months pre-listing dialysis time, with significant center-level variation. High-KDPI consent was associated with higher rates of DDTX(Adjusted Hazard Ratio=1.15,95% Confidence Interval=1.13,1.17) with no difference in likelihood of DDTX from donors with KDPI<85%. The effect of high-KDPI consent on higher rates of DDTx was higher among candidates ages >60 years and diabetic candidates and variable based on center characteristics.
Conclusions
There is significant variation of consent for high-KDPI donor kidneys and higher likelihood of transplantation associated with consent.